New research suggests that individuals who come off blockbuster slimming jabs like Wegovy and Mounjaro tend to recover shed pounds far faster than those who halt traditional diet and exercise regimens.
Research printed in a major medical journal shows that while overweight individuals can lose a large proportion of their body weight while on the medication, the mass returns at an average rate of 0.8 kg per month once they quit.
"Users buying such drugs need to be aware of the risk of quick weight regain when the medication ends," stated expert Dr. Susan Jebb.
That rate of regain suggests a reversion to pre-treatment mass within about 18 months.
Comparing Treatments
The analysis, which reviewed 37 of trials involving thousands of participants, compared the results of GLP-1 agonists with older methods.
Scientists emphasize that people who lose weight through dieting generally experience a slower weight regain—around 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Nutrition scientists suggest the way of the injections explains the accelerated rebound.
The injections imitate a body's own chemical called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 levels far above than normal may cause the body to produce less of its endogenous hormone, and could diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication leads to appetite is unsuppressed, making binge eating much more probable."
A Chronic Disease?
Health authorities suggest the jabs for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Professionals say that, considering the likelihood of relapse, the therapy should be considered life-long.
This perspective is echoed by pharmaceutical companies, who note that the findings "underscore the long-term nature of obesity," similar to managing diseases like hypertension.
Patient Testimonies
Individuals who have discontinued the jabs report a powerful resurgence of cravings.
"It felt as if a switch activating and you're instantly starving," recalled a patient.
This challenge is exacerbated if individuals have not established lasting lifestyle or habit modifications during treatment.
Growing Adoption
Figures show that a significant number of people in the UK have used these injections in the past year, with desire remaining high.
- Use is higher among women than men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
Ultimately, researchers emphasize that while the jabs are potent agents for shedding pounds, they are not a permanent solution and maintained weight loss hinges on ongoing lifestyle support.
